In this field, choices are endless. Still, Espresso is my pick. A beautifully designed interface adds visual pleasure to your workflow. And the work certainly flows with Espresso! Thanks to supersmart autocompletion (way above the competition), the coolest navigator you’ll find, and a huge set of addons (smartly called Sugars) you will certainly find Espresso the right tool for your web editing duties. The visual guys will find the CSS panel particularly useful, while those coming from pure-text editors will be able to customize syntax highlighting to their hearts’ content and use custom code snippets. Give it a check, there’s a 15-day trial to taste a cup of web editing the way it’s meant to be.